Cardiac fibrosis in mice expressing an inducible myocardial-specific Cre driver

• Main Authors: Jonas Lexow (Author), Tommaso Poggioli (Author), Padmini Sarathchandra (Author), Maria Paola Santini (Author), Nadia Rosenthal (Author)
• Format: Book
• Published: The Company of Biologists, 2013-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Tamoxifen-inducible Cre-mediated manipulation of animal genomes has achieved wide acceptance over the last decade, with numerous important studies heavily relying on this technique. Recently, a number of groups have reported transient complications of using this protocol in the heart. In the...