NB compounds are potent and efficacious FOXM1 inhibitors in high-grade serous ovarian cancer cells

• Main Authors: Cassie Liu (Author), Makenzie Vorderbruggen (Author), Catalina Muñoz-Trujillo (Author), Sung Hoon Kim (Author), John A. Katzenellenbogen (Author), Benita S. Katzenellenbogen (Author), Adam R. Karpf (Author)
• Format: Book
• Published: BMC, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Genetic studies implicate the oncogenic transcription factor Forkhead Box M1 (FOXM1) as a potential therapeutic target in high-grade serous ovarian cancer (HGSOC). We evaluated the activity of different FOXM1 inhibitors in HGSOC cell models. Results We treated HGSOC and fallopian...