Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy

• Main Authors: Nikolas T. Martin (Author), Mathieu J. F. Crupi (Author), Zaid Taha (Author), Joanna Poutou (Author), Jack T. Whelan (Author), Sydney Vallati (Author), Julia Petryk (Author), Ricardo Marius (Author), Bradley Austin (Author), Taha Azad (Author), Mason Boulanger (Author), Tamara Burgess (Author), Ilson Sanders (Author), Camille Victoor (Author), Bryan C. Dickinson (Author), Jean-Simon Diallo (Author), Carolina S. Ilkow (Author), John C. Bell (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The approval of different cytokines as anti-neoplastic agents has been challenged by dose-limiting toxicities. Although reducing dose levels affords improved tolerability, efficacy is precluded at these suboptimal doses. Strategies combining cytokines with oncolytic viruses have proven to elicit pot...