Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy

• Главные авторы: Nikolas T. Martin (Автор), Mathieu J. F. Crupi (Автор), Zaid Taha (Автор), Joanna Poutou (Автор), Jack T. Whelan (Автор), Sydney Vallati (Автор), Julia Petryk (Автор), Ricardo Marius (Автор), Bradley Austin (Автор), Taha Azad (Автор), Mason Boulanger (Автор), Tamara Burgess (Автор), Ilson Sanders (Автор), Camille Victoor (Автор), Bryan C. Dickinson (Автор), Jean-Simon Diallo (Автор), Carolina S. Ilkow (Автор), John C. Bell (Автор)
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• Опубликовано: MDPI AG, 2023-05-01T00:00:00Z.
• Предметы: article
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The approval of different cytokines as anti-neoplastic agents has been challenged by dose-limiting toxicities. Although reducing dose levels affords improved tolerability, efficacy is precluded at these suboptimal doses. Strategies combining cytokines with oncolytic viruses have proven to elicit pot...