A novel Mutein of TNFα Containing the Arg-Gly-Asp Sequence Shows Reduced Toxicity in Intestine

• मुख्य लेखकों: H. Shikama (लेखक), K. Miyata (लेखक), N. Sakae (लेखक), K. Kuroda (लेखक), K. Nishimura (लेखक), S. Yotsuya (लेखक), M. Kato (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Hindawi Limited, 1994-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The effects of human tumour necrosis factor-α (TNFα), or its mutein (F4168) having the cell adhesive Arg-Gly-Asp sequence at the N-terminus, on intestinal injury, were examined. Histopathological examination revealed that an intravenous injection of TNFα resulted in marked haemorrhage or oedema in t...