A novel Mutein of TNFα Containing the Arg-Gly-Asp Sequence Shows Reduced Toxicity in Intestine

• Ngā kaituhi matua: H. Shikama (Author), K. Miyata (Author), N. Sakae (Author), K. Kuroda (Author), K. Nishimura (Author), S. Yotsuya (Author), M. Kato (Author)
• Hōputu: Pukapuka
• I whakaputaina: Hindawi Limited, 1994-01-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

The effects of human tumour necrosis factor-α (TNFα), or its mutein (F4168) having the cell adhesive Arg-Gly-Asp sequence at the N-terminus, on intestinal injury, were examined. Histopathological examination revealed that an intravenous injection of TNFα resulted in marked haemorrhage or oedema in t...