Screening and Identification of Key Biomarkers in Acquired Lapatinib-Resistant Breast Cancer

• Main Authors: Shengnan Bao (Author), Yi Chen (Author), Fan Yang (Author), Chunxiao Sun (Author), Mengzhu Yang (Author), Wei Li (Author), Xiang Huang (Author), Jun Li (Author), Hao Wu (Author), Yongmei Yin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lapatinib, targeting the human epidermal growth factor receptor family members HER1 and HER2, has been approved by the US Food and Drug Administration for use in metastatic HER2-positive breast cancer. However, resistance to lapatinib remains a common challenge to HER2-positive metastatic breast can...