The G-protein-coupled bile acid receptor Gpbar1 (TGR5) inhibits gastric inflammation through antagonizing NF-kB signaling pathway

• Main Authors: Cong eGuo (Author), Hui eQi (Author), Yingjie eYu (Author), Qiqi eZhang (Author), Jia eSu (Author), Donna eYu (Author), Wendong eHuang (Author), Wei-Dong eChen (Author), YAN-DONG eWANG (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well known for its roles in regulation of energy homeostasis and glucose metabolism. Here we show that mice lacking TGR5 were much more susceptible to lipopolysaccharide (LPS)-induced acute gastric inflammation than wild-type (WT) mice and TGR5...