Paromomycin for the treatment of visceral leishmaniasis in Sudan: a randomized, open-label, dose-finding study.

• Main Authors: Ahmed M Musa (Author), Brima Younis (Author), Ahmed Fadlalla (Author), Catherine Royce (Author), Manica Balasegaram (Author), Monique Wasunna (Author), Asrat Hailu (Author), Tansy Edwards (Author), Raymond Omollo (Author), Mahmoud Mudawi (Author), Gilbert Kokwaro (Author), Ahmed El-Hassan (Author), Eltahir Khalil (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A recent study has shown that treatment of visceral leishmaniasis (VL) with the standard dose of 15 mg/kg/day of paromomycin sulphate (PM) for 21 days was not efficacious in patients in Sudan. We therefore decided to test the efficacy of paramomycin for a longer treatment duration (15 mg/kg/day for...