Population pharmacokinetics of everolimus in adult liver transplant patients: Comparison to tacrolimus disposition and extrapolation to pediatrics

• Main Authors: Kotaro Itohara (Author), Ikuko Yano (Author), Shunsaku Nakagawa (Author), Mitsuhiro Sugimoto (Author), Machiko Hirai (Author), Atsushi Yonezawa (Author), Satoshi Imai (Author), Takayuki Nakagawa (Author), Daiki Hira (Author), Takashi Ito (Author), Koichiro Hata (Author), Etsuro Hatano (Author), Tomohiro Terada (Author), Kazuo Matsubara (Author)
• Format: Book
• Published: Wiley, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Everolimus has recently been used to prevent graft rejection in liver transplantation and reduces the incidence of kidney dysfunction caused by calcineurin inhibitors. In this study, a population pharmacokinetic analysis was conducted to improve the individualization of everolimus therapy....