Cellular mechanisms underlying the inhibitory effect of flufenamic acid on chloride secretion in human intestinal epithelial cells

• Үндсэн зохиолчид: Pawin Pongkorpsakol (Зохиогч), Chantapol Yimnual (Зохиогч), Varanuj Chatsudthipong (Зохиогч), Vatcharin Rukachaisirikul (Зохиогч), Chatchai Muanprasat (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2017-06-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Intestinal Cl− secretion is involved in the pathogenesis of secretory diarrheas including cholera. We recently demonstrated that flufenamic acid (FFA) suppressed Vibrio cholerae El Tor variant-induced intestinal fluid secretion via mechanisms involving AMPK activation and NF-κB-suppression. The pres...