Bioadhesive hybrid system of niosomes and pH sensitive in situ gel for itraconazole ocular delivery: Dual approach for efficient treatment of fungal infections

• Main Authors: Mohamed M. Badran (Author), Areej Alsubaie (Author), Mounir M. Salem Bekhit (Author), Abdullah H. Alomrani (Author), Aliyah Almomen (Author), Mohamed Abbas Ibrahim (Author), Doaa Hasan Alshora (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Itraconazole (ITZ) is a highly effective antifungal agent. However, its oral application is associated with systemic toxicity and poor topical use. The present study aims to improve the antifungal activity of ITZ by loading it into bioadhesive niosomes. This approach is considered to enhance the ocu...