A Selective Inhibitor of Human C-reactive Protein Translation Is Efficacious In Vitro and in C-reactive Protein Transgenic Mice and Humans

• Main Authors: Nicholas R Jones (Author), Melissa A Pegues (Author), Mark A McCrory (Author), Walter Singleton (Author), Claudette Bethune (Author), Brenda F Baker (Author), Daniel A Norris (Author), Rosanne M Crooke (Author), Mark J Graham (Author), Alexander J Szalai (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Observational studies of patients with established rheumatoid arthritis (RA) document a positive correlation between C-reactive protein (CRP) blood concentration and worsening of RA symptoms, but whether this association is causal or not is not known. Using CRP transgenic mice (CRPTg) with collagen-...