Nitric oxide synthase phosphorylation in fetoplacental endothelium is enhanced by agonism of Piezo1 mechanosensor in small for gestational age babies

• Main Authors: L C Morley (Author), M Debant (Author), H J Gaunt (Author), N A B Simpson (Author), D J Beech (Author)
• Format: Book
• Published: Bioscientifica, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Friction caused by blood flowing across cells that line blood vessels (endothelial cells) activates sensors of mechanical force. This produces nitric oxide (NO) which widens placental blood vessels, enabling more blood flow to the baby. This study sought to determine whether the mechanical sensor, P...