A pilot study of cerebral metabolism and serotonin 5-HT2A receptor occupancy in rats treated with the psychedelic tryptamine DMT in conjunction with the MAO inhibitor harmine

• Main Authors: Klemens Egger (Author), Frederik Gudmundsen (Author), Naja Støckel Jessen (Author), Christina Baun (Author), Sandra N. Poetzsch (Author), Vladimir Shalgunov (Author), Matthias M. Herth (Author), Boris B. Quednow (Author), Chantal Martin-Soelch (Author), Dario Dornbierer (Author), Milan Scheidegger (Author), Paul Cumming (Author), Mikael Palner (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rationale: The psychedelic effects of the traditional Amazonian botanical decoction known as ayahuasca are often attributed to agonism at brain serotonin 5-HT2A receptors by N,N-dimethyltryptamine (DMT). To reduce first pass metabolism of oral DMT, ayahuasca preparations additionally contain reversi...