CONSTRUCTION OF IN SILICO STRUCTURE-BASED SCREENING TOOLS TO STUDY THE OXIDATIVE METABOLITES FORMATION OF CURCUMIN BY HUMAN CYTOCHROME 450 3A4

• প্রধান লেখক: Dewi Setyaningsih (Author), Muhammad Radifar (Author), Yosi Bayu Murti (Author), Enade Perdana Istyastono (Author)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Universitas Gadjah Mada, 2013-04-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Cytochrome P450 3A4 (CYP3A4) is a phase 1 metabolism enzyme which is responsible for the metabolism of about 3040% drug in the market. This CYP3A4 is the most abundant CYP450 expressed in human body and also the one who is responsible for the biotransformation of most drugs. The competitive inhibiti...