NAC and Vitamin D Improve CNS and Plasma Oxidative Stress in Neonatal HIE and Are Associated with Favorable Long-Term Outcomes

• Główni autorzy: Dorothea D Jenkins (Autor), Hunter G Moss (Autor), Truman R Brown (Autor), Milad Yazdani (Autor), Sudhin Thayyil (Autor), Paolo Montaldo (Autor), Maximo Vento (Autor), Julia Kuligowski (Autor), Carol Wagner (Autor), Bruce W Hollis (Autor), Donald B Wiest (Autor)
• Format: Książka
• Wydane: MDPI AG, 2021-08-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

N-acetylcysteine (NAC) and vitamin D provide effective neuroprotection in animal models of severe or inflammation-sensitized hypoxic ischemic encephalopathy (HIE). To translate these FDA-approved drugs to HIE neonates, we conducted an early phase, open-label trial of 10 days of NAC (25, 40 mg/kg q12...