NAC and Vitamin D Improve CNS and Plasma Oxidative Stress in Neonatal HIE and Are Associated with Favorable Long-Term Outcomes

• Main Authors: Dorothea D Jenkins (Author), Hunter G Moss (Author), Truman R Brown (Author), Milad Yazdani (Author), Sudhin Thayyil (Author), Paolo Montaldo (Author), Maximo Vento (Author), Julia Kuligowski (Author), Carol Wagner (Author), Bruce W Hollis (Author), Donald B Wiest (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

N-acetylcysteine (NAC) and vitamin D provide effective neuroprotection in animal models of severe or inflammation-sensitized hypoxic ischemic encephalopathy (HIE). To translate these FDA-approved drugs to HIE neonates, we conducted an early phase, open-label trial of 10 days of NAC (25, 40 mg/kg q12...