Cardiac safety assessment of a novel recombinant bispecific antibody targeting the ether-à-go-go related gene 1 (hERG1)-β1 integrin macromolecular complex

• Main Authors: Lorenzo Santini (Author), Claudia Duranti (Author), Chiara Palandri (Author), Lucrezia Giammarino (Author), Monica Musumeci (Author), Lucia Carlucci (Author), Chiara Capitani (Author), Rossella Colasurdo (Author), Fabio Recchia (Author), Elisabetta Cerbai (Author), Raffaele Coppini (Author), Annarosa Arcangeli (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: In the last decades, mounting evidence has pointed out the human ether-á-go-go-related gene (hERG1) potassium channel as a novel biomarker in human cancers. However, hERG1 sustains the cardiac repolarizing current IKr and its blockade can induce a prolonged QT interval at the ECG, whic...