Cardiac safety assessment of a novel recombinant bispecific antibody targeting the ether-à-go-go related gene 1 (hERG1)-β1 integrin macromolecular complex

• मुख्य लेखकों: Lorenzo Santini (लेखक), Claudia Duranti (लेखक), Chiara Palandri (लेखक), Lucrezia Giammarino (लेखक), Monica Musumeci (लेखक), Lucia Carlucci (लेखक), Chiara Capitani (लेखक), Rossella Colasurdo (लेखक), Fabio Recchia (लेखक), Elisabetta Cerbai (लेखक), Raffaele Coppini (लेखक), Annarosa Arcangeli (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2023-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Introduction: In the last decades, mounting evidence has pointed out the human ether-á-go-go-related gene (hERG1) potassium channel as a novel biomarker in human cancers. However, hERG1 sustains the cardiac repolarizing current IKr and its blockade can induce a prolonged QT interval at the ECG, whic...