Combination of AAV-delivered tumor suppressor PTEN with anti-PD-1 loaded depot gel for enhanced antitumor immunity

• Main Authors: Yongshun Zhang (Author), Lan Yang (Author), Yangsen Ou (Author), Rui Hu (Author), Guangsheng Du (Author), Shuang Luo (Author), Fuhua Wu (Author), Hairui Wang (Author), Zhiqiang Xie (Author), Yu Zhang (Author), Chunting He (Author), Cheng Ma (Author), Tao Gong (Author), Ling Zhang (Author), Zhirong Zhang (Author), Xun Sun (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent clinical studies have shown that mutation of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene in cancer cells may be associated with immunosuppressive tumor microenvironment (TME) and poor response to immune checkpoint blockade (ICB) therapy. Therefore, efficiently restorin...