Selection of Suitable Prodrug Candidates for in vivo Studies via in vitro Studies; The Correlation of Prodrug Stability in Between Cell Culture Homogenates and Human Tissue Homogenates

• Հիմնական հեղինակներ: Yasuhiro Tsume (Հեղինակ), Gordon L Amidon (Հեղինակ)
• Ձևաչափ: Գիրք
• Հրապարակվել է: Frontiers Media S.A., 2012-07-01T00:00:00Z.
• Խորագրեր: article
• Առցանց հասանելիություն: Connect to this object online.

Purpose. To determine the correlations/discrepancies of drug stabilities between in the homogenates of human culture cells and of human tissues. Methods. Amino acid/dipeptide monoester prodrugs of floxuridine were chosen as the model drugs. The stabilities (half-lives) of floxuridine prodrugs in hum...