HYD-PEP06 suppresses hepatocellular carcinoma metastasis, epithelial-mesenchymal transition and cancer stem cell-like properties by inhibiting PI3K/AKT and WNT/β-catenin signaling activation

• Hoofdauteurs: Wei Tian (Auteur), Jiatong Li (Auteur), Zhuo Wang (Auteur), Tong Zhang (Auteur), Ying Han (Auteur), Yanyan Liu (Auteur), Wenfeng Chu (Auteur), Yu Liu (Auteur), Baofeng Yang (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2021-06-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

HYD-PEP06, an endostatin-modified polypeptide, has been shown to produce effective anti-colorectal carcinoma effects through inhibiting epithelial-mesenchymal transition (EMT). However, whether HYD-PEP06 has similar suppressive effect on hepatocellular carcinoma (HCC) remained unknown. In this study...