Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 Drosophila model

• Главные авторы: Ariadna Bargiela (Автор), Estefanía Cerro-Herreros (Автор), Juan M. Fernandez-Costa (Автор), Juan J. Vilchez (Автор), Beatriz Llamusi (Автор), Ruben Artero (Автор)
• Формат: ‌
• Опубликовано: The Company of Biologists, 2015-07-01T00:00:00Z.
• Предметы: article
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Muscle mass wasting is one of the most debilitating symptoms of myotonic dystrophy type 1 (DM1) disease, ultimately leading to immobility, respiratory defects, dysarthria, dysphagia and death in advanced stages of the disease. In order to study the molecular mechanisms leading to the degenerative lo...