Add-On Aliskiren Elicits Stronger Renoprotection Than High-Dose Valsartan in Type 2 Diabetic KKAy Mice That Do Not Respond to Low-Dose Valsartan

• Egile Nagusiak: Bai Lei (Egilea), Daisuke Nakano (Egilea), Yu-Yan Fan (Egilea), Kento Kitada (Egilea), Hirofumi Hitomi (Egilea), Hiroyuki Kobori (Egilea), Hirohito Mori (Egilea), Tsutomu Masaki (Egilea), Akira Nishiyama (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2012-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

We hypothesized that aliskiren provides renoprotection in diabetic animals that did not receive sufficient renoprotection by AT1-receptor antagonist treatment. Type 2 diabetic KKAy mice were treated with group 1: vehicle or group 2: valsartan (15 mg/kg per day) from 12 to 16 weeks of age. The mice w...