Add-On Aliskiren Elicits Stronger Renoprotection Than High-Dose Valsartan in Type 2 Diabetic KKAy Mice That Do Not Respond to Low-Dose Valsartan

• मुख्य लेखकों: Bai Lei (लेखक), Daisuke Nakano (लेखक), Yu-Yan Fan (लेखक), Kento Kitada (लेखक), Hirofumi Hitomi (लेखक), Hiroyuki Kobori (लेखक), Hirohito Mori (लेखक), Tsutomu Masaki (लेखक), Akira Nishiyama (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2012-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

We hypothesized that aliskiren provides renoprotection in diabetic animals that did not receive sufficient renoprotection by AT1-receptor antagonist treatment. Type 2 diabetic KKAy mice were treated with group 1: vehicle or group 2: valsartan (15 mg/kg per day) from 12 to 16 weeks of age. The mice w...