Add-On Aliskiren Elicits Stronger Renoprotection Than High-Dose Valsartan in Type 2 Diabetic KKAy Mice That Do Not Respond to Low-Dose Valsartan

• Principais autores: Bai Lei (Autor), Daisuke Nakano (Autor), Yu-Yan Fan (Autor), Kento Kitada (Autor), Hirofumi Hitomi (Autor), Hiroyuki Kobori (Autor), Hirohito Mori (Autor), Tsutomu Masaki (Autor), Akira Nishiyama (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2012-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

We hypothesized that aliskiren provides renoprotection in diabetic animals that did not receive sufficient renoprotection by AT1-receptor antagonist treatment. Type 2 diabetic KKAy mice were treated with group 1: vehicle or group 2: valsartan (15 mg/kg per day) from 12 to 16 weeks of age. The mice w...