An anti-tuberculosis compound screen using a zebrafish infection model identifies an aspartyl-tRNA synthetase inhibitor

• Main Authors: Eva Habjan (Author), Vien Q. T. Ho (Author), James Gallant (Author), Gunny van Stempvoort (Author), Kin Ki Jim (Author), Coen Kuijl (Author), Daan P. Geerke (Author), Wilbert Bitter (Author), Alexander Speer (Author)
• Format: Book
• Published: The Company of Biologists, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Finding new anti-tuberculosis compounds with convincing in vivo activity is an ongoing global challenge to fight the emergence of multidrug-resistant Mycobacterium tuberculosis isolates. In this study, we exploited the medium-throughput capabilities of the zebrafish embryo infection model with Mycob...