BALB/c mice infected with antimony treatment refractory isolate of Leishmania braziliensis present severe lesions due to IL-4 production.

• Main Authors: Diego L Costa (Author), Vanessa Carregaro (Author), Djalma S Lima-Júnior (Author), Neide M Silva (Author), Cristiane M Milanezi (Author), Cristina R Cardoso (Author), Ângela Giudice (Author), Amélia R de Jesus (Author), Edgar M Carvalho (Author), Roque P Almeida (Author), João S Silva (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Leishmania braziliensis is the main causative agent of cutaneous leishmaniasis in Brazil. Protection against infection is related to development of Th1 responses, but the mechanisms that mediate susceptibility are still poorly understood. Murine models have been the most important tools...