Therapeutic Potential of an Azithromycin-Colistin Combination against XDR <i>K. pneumoniae</i> in a 3D Collagen-Based In Vitro Wound Model of a Biofilm Infection

• Main Authors: Olena V. Moshynets (Author), Taras P. Baranovskyi (Author), Olga S. Iungin (Author), Alexey A. Krikunov (Author), Viktoria V. Potochilova (Author), Kateryna L. Rudnieva (Author), Geert Potters (Author), Ianina Pokholenko (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A therapeutic combination of azithromycin (AZM) and colistin methanesulfonate (CMS) was shown to be effective against both non-PDR and PDR <i>Klebsiella pneumoniae</i> biofilms in vitro. These anti-biofilm effects, however, may not correlate with effects observed in standard plate assays...