Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence

• Main Authors: Huizhen Zhang (Author), Yongtao Wang (Author), Lihuan Guan (Author), Yixin Chen (Author), Panpan Chen (Author), Jiahong Sun (Author), Frank J. Gonzalez (Author), Min Huang (Author), Huichang Bi (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lipotoxicity, caused by intracellular lipid accumulation, accelerates the degenerative process of cellular senescence, which has implications in cancer development and therapy. Previously, carnitine palmitoyltransferase 1C (CPT1C), a mitochondrial enzyme that catalyzes carnitinylation of fatty acids...