Blockade of the JNK Signalling as a Rational Therapeutic Approach to Modulate the Early and Late Steps of the Inflammatory Cascade in Polymicrobial Sepsis

• Main Authors: Gabriele Pizzino (Author), Alessandra Bitto (Author), Giovanni Pallio (Author), Natasha Irrera (Author), Federica Galfo (Author), Monica Interdonato (Author), Anna Mecchio (Author), Filippo De Luca (Author), Letteria Minutoli (Author), Francesco Squadrito (Author), Domenica Altavilla (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cecal ligation and puncture (CLP) is an experimental polymicrobial sepsis induced systemic inflammation that leads to acute organ failure. Aim of our study was to evaluate the effects of SP600125, a specific c-Jun NH2-terminal kinase (JNK) inhibitor, to modulate the early and late steps of the infla...