Leprosy Reactions Show Increased Th17 Cell Activity and Reduced FOXP3+ Tregs with Concomitant Decrease in TGF-β and Increase in IL-6.

• Asıl Yazarlar: Chaman Saini (Yazar), Anisuddin Siddiqui (Yazar), Venkatesh Ramesh (Yazar), Indira Nath (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Public Library of Science (PLoS), 2016-04-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

BACKGROUND:50% of leprosy patients suffer from episodes of Type 1/ reversal reactions (RR) and Type 2/ Erythema Nodosum Leprosum (ENL) reactions which lead to morbidity and nerve damage. CD4+ subsets of Th17 cells and CD25+FOXP3+ regulatory T cells (Tregs) have been shown to play a major role in dis...