Pulmonary delivery of influenza vaccine formulations in cotton rats: site of deposition plays a minor role in the protective efficacy against clinical isolate of H1N1pdm virus

• Main Authors: Yoshita Bhide (Author), Jasmine Tomar (Author), Wei Dong (Author), Jacqueline de Vries-Idema (Author), Henderik W. Frijlink (Author), Anke Huckriede (Author), Wouter L. J. Hinrichs (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Administration of influenza vaccines to the lungs could be an attractive alternative to conventional parenteral administration. In this study, we investigated the deposition site of pulmonary delivered liquid and powder influenza vaccine formulations and its relation to their immunogenicity and prot...