Lack of Correlation between In Vitro and In Vivo Studies on the Inhibitory Effects of (‒)-Sophoranone on CYP2C9 Is Attributable to Low Oral Absorption and Extensive Plasma Protein Binding of (‒)-Sophoranone

• Main Authors: Yu Fen Zheng (Author), Soo Hyeon Bae (Author), Zhouchi Huang (Author), Soon Uk Chae (Author), Seong Jun Jo (Author), Hyung Joon Shim (Author), Chae Bin Lee (Author), Doyun Kim (Author), Hunseung Yoo (Author), Soo Kyung Bae (Author)
• Format: Book
• Published: MDPI AG, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

(‒)-Sophoranone (SPN) is a bioactive component of <i>Sophora tonkinensis</i> with various pharmacological activities. This study aims to evaluate its in vitro and in vivo inhibitory potential against the nine major CYP enzymes. Of the nine tested CYPs, it exerted the strongest inhibitory...