Inhibition of the ROS-EGFR Pathway Mediates the Protective Action of Nox1/4 Inhibitor GKT137831 against Hypertensive Cardiac Hypertrophy via Suppressing Cardiac Inflammation and Activation of Akt and ERK1/2

• Main Authors: Si-yu Zeng (Author), Qiu-jiang Yan (Author), Li Yang (Author), Qing-hua Mei (Author), Hui-qin Lu (Author)
• 格式: 图书
• 出版: Hindawi Limited, 2020-01-01T00:00:00Z.
• 主题: article
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Oxidative stress, inflammation, and hypertension constitute a self-perpetuating vicious circle to exacerbate hypertension and subsequent hypertensive cardiac hypertrophy. NADPH oxidase (Nox) 1/4 inhibitor GKT137831 alleviates hypertensive cardiac hypertrophy in models of secondary hypertension; howe...