Mexiletine Reverses Oxaliplatin-Induced Neuropathic Pain in Rats

• Main Authors: Nobuaki Egashira (Author), Shingo Hirakawa (Author), Takehiro Kawashiri (Author), Takahisa Yano (Author), Hiroaki Ikesue (Author), Ryozo Oishi (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxaliplatin is a platinum-based chemotherapy drug characterized by the development of acute and chronic peripheral neuropathies. Mexiletine, an orally available Na+-channel blocker, has widely been used in patients with chronic painful diabetic neuropathy. In the present study, we examined the effec...