Immune Checkpoint Inhibitors Regulate K+ Channel Activity in Cytotoxic T Lymphocytes of Head and Neck Cancer Patients

• Main Authors: Vaibhavkumar S. Gawali (Author), Ameet A. Chimote (Author), Hannah S. Newton (Author), Manuel G. Feria-Garzón (Author), Martina Chirra (Author), Edith M. Janssen (Author), Trisha M. Wise-Draper (Author), Laura Conforti (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Programmed death receptor-1 (PD-1) and its ligand (PD-L1) interaction negatively regulates T cell function in head and neck squamous cell carcinoma (HNSCC). Overexpression of PD-1 reduces intracellular Ca2+ fluxes, and thereby T cell effector functions. In HNSCC patients, PD-1 blockade increases KCa...