Immune Checkpoint Inhibitors Regulate K+ Channel Activity in Cytotoxic T Lymphocytes of Head and Neck Cancer Patients

• Главные авторы: Vaibhavkumar S. Gawali (Автор), Ameet A. Chimote (Автор), Hannah S. Newton (Автор), Manuel G. Feria-Garzón (Автор), Martina Chirra (Автор), Edith M. Janssen (Автор), Trisha M. Wise-Draper (Автор), Laura Conforti (Автор)
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• Опубликовано: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Предметы: article
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Programmed death receptor-1 (PD-1) and its ligand (PD-L1) interaction negatively regulates T cell function in head and neck squamous cell carcinoma (HNSCC). Overexpression of PD-1 reduces intracellular Ca2+ fluxes, and thereby T cell effector functions. In HNSCC patients, PD-1 blockade increases KCa...