Polyhydroxyalkanoate/Antifungal Polyene Formulations with Monomeric Hydroxyalkanoic Acids for Improved Antifungal Efficiency

• Main Authors: Marina Pekmezovic (Author), Melina Kalagasidis Krusic (Author), Ivana Malagurski (Author), Jelena Milovanovic (Author), Karolina Stępień (Author), Maciej Guzik (Author), Romina Charifou (Author), Ramesh Babu (Author), Kevin O'Connor (Author), Jasmina Nikodinovic-Runic (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Novel biodegradable and biocompatible formulations of "old" but "gold" drugs such as nystatin (Nys) and amphotericin B (AmB) were made using a biopolymer as a matrix. Medium chain length polyhydroxyalkanoates (mcl-PHA) were used to formulate both polyenes (Nys and AmB) in the for...