Normal versus Pathological Cardiac Fibroblast-Derived Extracellular Matrix Differentially Modulates Cardiosphere-Derived Cell Paracrine Properties and Commitment

• Egile Nagusiak: Francesca Pagano (Egilea), Francesco Angelini (Egilea), Clotilde Castaldo (Egilea), Vittorio Picchio (Egilea), Elisa Messina (Egilea), Sebastiano Sciarretta (Egilea), Ciro Maiello (Egilea), Giuseppe Biondi-Zoccai (Egilea), Giacomo Frati (Egilea), Franca di Meglio (Egilea), Daria Nurzynska (Egilea), Isotta Chimenti (Egilea)
• Formatua: Liburua
• Argitaratua: Hindawi Limited, 2017-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Human resident cardiac progenitor cells (CPCs) isolated as cardiosphere-derived cells (CDCs) are under clinical evaluation as a therapeutic product for cardiac regenerative medicine. Unfortunately, limited engraftment and differentiation potential of transplanted cells significantly hamper therapeut...