Normal versus Pathological Cardiac Fibroblast-Derived Extracellular Matrix Differentially Modulates Cardiosphere-Derived Cell Paracrine Properties and Commitment

• Main Authors: Francesca Pagano (Author), Francesco Angelini (Author), Clotilde Castaldo (Author), Vittorio Picchio (Author), Elisa Messina (Author), Sebastiano Sciarretta (Author), Ciro Maiello (Author), Giuseppe Biondi-Zoccai (Author), Giacomo Frati (Author), Franca di Meglio (Author), Daria Nurzynska (Author), Isotta Chimenti (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human resident cardiac progenitor cells (CPCs) isolated as cardiosphere-derived cells (CDCs) are under clinical evaluation as a therapeutic product for cardiac regenerative medicine. Unfortunately, limited engraftment and differentiation potential of transplanted cells significantly hamper therapeut...