Chronic Ethanol Feeding Modulates Inflammatory Mediators, Activation of Nuclear Factor-κB, and Responsiveness to Endotoxin in Murine Kupffer Cells and Circulating Leukocytes

• Main Authors: Miriam Maraslioglu (Author), Elsie Oppermann (Author), Carolin Blattner (Author), Roxane Weber (Author), Dirk Henrich (Author), Christian Jobin (Author), Elke Schleucher (Author), Ingo Marzi (Author), Mark Lehnert (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic ethanol abuse is known to increase susceptibility to infections after injury, in part, by modification of macrophage function. Several intracellular signalling mechanisms are involved in the initiation of inflammatory responses, including the nuclear factor-κB (NF-κB) pathway. In this study,...