Epigallocatechin-3-gallate Ameliorates Seawater Aspiration-Induced Acute Lung Injury via Regulating Inflammatory Cytokines and Inhibiting JAK/STAT1 Pathway in Rats

• Main Authors: Wei Liu (Author), Mingqing Dong (Author), Liyan Bo (Author), Congcong Li (Author), Qingqing Liu (Author), Yanyan Li (Author), Lijie Ma (Author), Yonghong Xie (Author), Enqing Fu (Author), Deguang Mu (Author), Lei Pan (Author), Faguang Jin (Author), Zhichao Li (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Signal transducers and activators of transcriptions 1 (STAT1) play an important role in the inflammation process of acute lung injury (ALI). Epigallocatechin-3-gallate (EGCG) exhibits a specific and strong anti-STAT1 activity. Therefore, our study is to explore whether EGCG pretreatment can ameliora...