Optimisation of a Greener-Approach for the Synthesis of Cyclodextrin-Based Nanosponges for the Solubility Enhancement of Domperidone, a BCS Class II Drug

• Principais autores: Mohit Vij (Autor), Neha Dand (Autor), Lalit Kumar (Autor), Pankaj Wadhwa (Autor), Shahid Ud Din Wani (Autor), Wael A. Mahdi (Autor), Sultan Alshehri (Autor), Prawez Alam (Autor), Faiyaz Shakeel (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2023-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

BCS class II molecules suffer from low oral bioavailability because of their poor permeability and sub-optimal aqueous solubility. One of the approaches to enhance their bioavailability is using cyclodextrin-based nanosponges. This study aimed to optimise and evaluate the feasibility of a microwave-...