Optimisation of a Greener-Approach for the Synthesis of Cyclodextrin-Based Nanosponges for the Solubility Enhancement of Domperidone, a BCS Class II Drug

• Main Authors: Mohit Vij (Author), Neha Dand (Author), Lalit Kumar (Author), Pankaj Wadhwa (Author), Shahid Ud Din Wani (Author), Wael A. Mahdi (Author), Sultan Alshehri (Author), Prawez Alam (Author), Faiyaz Shakeel (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BCS class II molecules suffer from low oral bioavailability because of their poor permeability and sub-optimal aqueous solubility. One of the approaches to enhance their bioavailability is using cyclodextrin-based nanosponges. This study aimed to optimise and evaluate the feasibility of a microwave-...