Misfolded α-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells

• Main Authors: Cathryn L. Ugalde (Author), Sarah J. Annesley (Author), Shane E. Gordon (Author), Katelyn Mroczek (Author), Matthew A. Perugini (Author), Victoria A. Lawson (Author), Paul R. Fisher (Author), David I. Finkelstein (Author), Andrew F. Hill (Author)
• Format: Book
• Published: The Company of Biologists, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The misfolding and aggregation of the largely disordered protein, α-synuclein, is a central pathogenic event that occurs in the synucleinopathies, a group of neurodegenerative disorders that includes Parkinson's disease. While there is a clear link between protein misfolding and neuronal vulner...