Integrating machine learning to construct aberrant alternative splicing event related classifiers to predict prognosis and immunotherapy response in patients with hepatocellular carcinoma

• Main Authors: Wangrui Liu (Author), Shuai Zhao (Author), Wenhao Xu (Author), Jianfeng Xiang (Author), Chuanyu Li (Author), Jun Li (Author), Han Ding (Author), Hailiang Zhang (Author), Yichi Zhang (Author), Haineng Huang (Author), Jian Wang (Author), Tao Wang (Author), Bo Zhai (Author), Lei Pan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: In hepatocellular carcinoma (HCC), alternative splicing (AS) is related to tumor invasion and progression.Methods: We used HCC data from a public database to identify AS subtypes by unsupervised clustering. Through feature analysis of different splicing subtypes and acquisition of the...