Dose-dependent artificial prolongation of prothrombin time by interaction between daptomycin and test reagents in patients receiving warfarin: a prospective in vivo clinical study

• Main Authors: Makoto Saito (Author), Shuji Hatakeyama (Author), Hideki Hashimoto (Author), Takumitsu Suzuki (Author), Daisuke Jubishi (Author), Makoto Kaneko (Author), Yukio Kume (Author), Takehito Yamamoto (Author), Hiroshi Suzuki (Author), Hiroshi Yotsuyanagi (Author)
• Format: Book
• Published: BMC, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Daptomycin has been reported to cause artificial prolongation of prothrombin time (PT) by interacting with some test reagents of PT. This prolongation was particularly prominent with high concentrations of daptomycin in vitro. However, whether this prolongation is important in cl...