Blockade of ICAM-1 Improves the Outcome of Polymicrobial Sepsis via Modulating Neutrophil Migration and Reversing Immunosuppression

• Main Authors: Yan-jun Zhao (Author), Wen-jing Yi (Author), Xiao-jian Wan (Author), Jun Wang (Author), Tian-zhu Tao (Author), Jin-bao Li (Author), Jia-feng Wang (Author), Xiao-ming Deng (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intercellular adhesion molecule-1 (ICAM-1) is a key adhesion molecule mediating neutrophil migration and infiltration during sepsis. But its role in the outcome of sepsis remains contradictory. The current study was performed to investigate the role of anti-ICAM-1 antibody in the outcome of polymicr...