Preclinical Pharmacokinetics and Biodistribution of Anticancer Dinuclear Palladium(II)-Spermine Complex (Pd₂Spm) in Mice

• Main Authors: Martin Vojtek (Author), Salomé Gonçalves-Monteiro (Author), Edgar Pinto (Author), Sára Kalivodová (Author), Agostinho Almeida (Author), Maria P. M. Marques (Author), Ana L. M. Batista de Carvalho (Author), Clara B. Martins (Author), Helder Mota-Filipe (Author), Isabel M. P. L. V. O. Ferreira (Author), Carmen Diniz (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Palladium-based compounds are regarded as potential analogs to platinum anticancer drugs with improved properties. The present study assessed the pharmacokinetics and biodistribution of a dinuclear palladium(II)-spermine chelate (Pd₂Spm), which has previously been shown to pos...