Dioscin Promotes Prostate Cancer Cell Apoptosis and Inhibits Cell Invasion by Increasing SHP1 Phosphorylation and Suppressing the Subsequent MAPK Signaling Pathway

• Main Authors: Shuyun He (Author), Jinrui Yang (Author), Shaobo Hong (Author), Haijian Huang (Author), Qingguo Zhu (Author), Liefu Ye (Author), Tao Li (Author), Xing Zhang (Author), Yongbao Wei (Author), Yunliang Gao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dioscin possesses antioxidant effects and has anticancer ability in many solid tumors including prostate cancer (PCa). Nevertheless, its effect and mechanism of anti-PCa action remain unclear. The tyrosine protein phosphatase SHP1, which contains an oxidation-sensitive domain, has been confirmed as...