Site-specific PEGylation of lidamycin and its antitumor activity

• Main Authors: Liang Li (Author), Boyang Shang (Author), Lei Hu (Author), Rongguang Shao (Author), Yongsu Zhen (Author)
• Format: Bog
• Udgivet: Elsevier, 2015-05-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

In this study, N-terminal site-specific mono-PEGylation of the recombinant lidamycin apoprotein (rLDP) of lidamycin (LDM) was prepared using a polyethyleneglycol (PEG) derivative (Mw 20 kDa) through a reactive terminal aldehyde group under weak acidic conditions (pH 5.5). The biochemical properties...