A pharmacokinetic drug-drug interaction study between rosuvastatin and emvododstat, a potent anti‐SARS‐CoV‐2 (COVID‐19) DHODH (dihydroorotate dehydrogenase) inhibitor

• Main Authors: Terri L. Morton (Author), Oscar L. Laskin (Author), Diksha Kaushik (Author), Lucy Lee (Author), Jiyuan Ma (Author), Allan Kristensen (Author), Kylie O'Keefe (Author), Lee Golden (Author), Matthew Klein (Author), Ronald Kong (Author)
• Format: Book
• Published: Wiley, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract A therapeutic agent that targets both viral replication and the hyper‐reactive immune response would offer a highly desirable treatment for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2; COVID‐19) management. Emvododstat (PTC299) was found to be a potent inhibitor of immunomod...