Upregulation of TLR4/MyD88 pathway in alcohol-induced Wernicke's encephalopathy: Findings in preclinical models and in a postmortem human case

• Main Authors: Marta Moya (Author), Berta Escudero (Author), Elena Gómez-Blázquez (Author), Ana Belen Rebolledo-Poves (Author), Meritxell López-Gallardo (Author), Carmen Guerrero (Author), Eva M. Marco (Author), Laura Orio (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Wernicke's encephalopathy (WE) is a neurologic disease caused by vitamin B1 or thiamine deficiency (TD), being the alcohol use disorder its main risk factor. WE patients present limiting motor, cognitive, and emotional alterations related to a selective cerebral vulnerability. Neuroinflammation...