Upregulation of TLR4/MyD88 pathway in alcohol-induced Wernicke's encephalopathy: Findings in preclinical models and in a postmortem human case

• Principais autores: Marta Moya (Autor), Berta Escudero (Autor), Elena Gómez-Blázquez (Autor), Ana Belen Rebolledo-Poves (Autor), Meritxell López-Gallardo (Autor), Carmen Guerrero (Autor), Eva M. Marco (Autor), Laura Orio (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Wernicke's encephalopathy (WE) is a neurologic disease caused by vitamin B1 or thiamine deficiency (TD), being the alcohol use disorder its main risk factor. WE patients present limiting motor, cognitive, and emotional alterations related to a selective cerebral vulnerability. Neuroinflammation...