Comparisons of Four Protein-Binding Models Characterizing the Pharmacokinetics of Unbound Phenytoin in Adult Patients Using Non-Linear Mixed-Effects Modeling
Abstract Background and objective Phenytoin is extensively protein bound with a narrow therapeutic range. The unbound phenytoin is pharmacologically active, but total concentrations are routinely measured in clinical practice. The relationship between free and total phenytoin has been described by v...
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| Main Authors: | , , , , , |
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| Format: | Book |
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Adis, Springer Healthcare,
2020-10-01T00:00:00Z.
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A1234.567 |
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