Comparisons of Four Protein-Binding Models Characterizing the Pharmacokinetics of Unbound Phenytoin in Adult Patients Using Non-Linear Mixed-Effects Modeling

• Egile Nagusiak: Heajin Jun (Egilea), Yan Rong (Egilea), Catharina Yih (Egilea), Jordan Ho (Egilea), Wendy Cheng (Egilea), Tony K. L. Kiang (Egilea)
• Formatua: Liburua
• Argitaratua: Adis, Springer Healthcare, 2020-10-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract Background and objective Phenytoin is extensively protein bound with a narrow therapeutic range. The unbound phenytoin is pharmacologically active, but total concentrations are routinely measured in clinical practice. The relationship between free and total phenytoin has been described by v...