Computational studies for pre-evaluation of pharmacological profile of gut microbiota-produced gliclazide metabolites

• Autores principales: Maja Đanić (Autor), Nebojša Pavlović (Autor), Dragana Zaklan (Autor), Bojan Stanimirov (Autor), Slavica Lazarević (Autor), Hani Al-Salami (Autor), Momir Mikov (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2024-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

BackgroundGliclazide, a second-generation sulfonylurea derivative still widely used as a second-line treatment for type 2 diabetes mellitus, is well known to be subject to interindividual differences in bioavailability, leading to variations in therapeutic responses among patients. Distinct gut micr...