Computational studies for pre-evaluation of pharmacological profile of gut microbiota-produced gliclazide metabolites

Computational studies for pre-evaluation of pharmacological profile of gut microbiota-produced gliclazide metabolites

BackgroundGliclazide, a second-generation sulfonylurea derivative still widely used as a second-line treatment for type 2 diabetes mellitus, is well known to be subject to interindividual differences in bioavailability, leading to variations in therapeutic responses among patients. Distinct gut micr...

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Main Authors: Maja Đanić (Author), Nebojša Pavlović (Author), Dragana Zaklan (Author), Bojan Stanimirov (Author), Slavica Lazarević (Author), Hani Al-Salami (Author), Momir Mikov (Author)
Format: Book
Published: Frontiers Media S.A., 2024-12-01T00:00:00Z.
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