Conjugation of Diclofenac with Novel Oleanolic Acid Derivatives Modulate Nrf2 and NF-κB Activity in Hepatic Cancer Cells and Normal Hepatocytes Leading to Enhancement of Its Therapeutic and Chemopreventive Potential

• Hoofdauteurs: Maria Narożna (Auteur), Violetta Krajka-Kuźniak (Auteur), Barbara Bednarczyk-Cwynar (Auteur), Małgorzata Kucińska (Auteur), Robert Kleszcz (Auteur), Jacek Kujawski (Auteur), Hanna Piotrowska-Kempisty (Auteur), Adam Plewiński (Auteur), Marek Murias (Auteur), Wanda Baer-Dubowska (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2021-07-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Combining NSAIDs with conventional therapeutics was recently explored as a new strategy in cancer therapy. Our earlier studies showed that novel oleanolic acid oximes (OAO) conjugated with aspirin or indomethacin may enhance their anti-cancer potential through modulation of the Nrf2 and NF-κB signal...