Conjugation of Diclofenac with Novel Oleanolic Acid Derivatives Modulate Nrf2 and NF-κB Activity in Hepatic Cancer Cells and Normal Hepatocytes Leading to Enhancement of Its Therapeutic and Chemopreventive Potential

• Main Authors: Maria Narożna (Author), Violetta Krajka-Kuźniak (Author), Barbara Bednarczyk-Cwynar (Author), Małgorzata Kucińska (Author), Robert Kleszcz (Author), Jacek Kujawski (Author), Hanna Piotrowska-Kempisty (Author), Adam Plewiński (Author), Marek Murias (Author), Wanda Baer-Dubowska (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Combining NSAIDs with conventional therapeutics was recently explored as a new strategy in cancer therapy. Our earlier studies showed that novel oleanolic acid oximes (OAO) conjugated with aspirin or indomethacin may enhance their anti-cancer potential through modulation of the Nrf2 and NF-κB signal...