Conjugation of Diclofenac with Novel Oleanolic Acid Derivatives Modulate Nrf2 and NF-κB Activity in Hepatic Cancer Cells and Normal Hepatocytes Leading to Enhancement of Its Therapeutic and Chemopreventive Potential

• প্রধান লেখক: Maria Narożna (লেখক), Violetta Krajka-Kuźniak (লেখক), Barbara Bednarczyk-Cwynar (লেখক), Małgorzata Kucińska (লেখক), Robert Kleszcz (লেখক), Jacek Kujawski (লেখক), Hanna Piotrowska-Kempisty (লেখক), Adam Plewiński (লেখক), Marek Murias (লেখক), Wanda Baer-Dubowska (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2021-07-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Combining NSAIDs with conventional therapeutics was recently explored as a new strategy in cancer therapy. Our earlier studies showed that novel oleanolic acid oximes (OAO) conjugated with aspirin or indomethacin may enhance their anti-cancer potential through modulation of the Nrf2 and NF-κB signal...